Patterns of mitochondrial sorting in yeast zygotes.
نویسندگان
چکیده
منابع مشابه
The Sorting of Mitochondrial DNA and Mitochondrial Proteins in Zygotes: Preferential Transmission of Mitochondrial DNA to the Medial Bud
Green fluorescent protein (GFP) was used to tag proteins of the mitochondrial matrix, inner, and outer membranes to examine their sorting patterns relative to mtDNA in zygotes of synchronously mated yeast cells in rho+ x rho0 crosses. When transiently expressed in one of the haploid parents, each of the marker proteins distributes throughout the fused mitochondrial reticulum of the zygote befor...
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Mitochondrial depolarization in yeast zygotes inhibits clonal expansion of selfish mtDNA.
Non-identical copies of mitochondrial DNA (mtDNA) compete with each other within a cell and the ultimate variant of mtDNA present depends on their relative replication rates. Using yeast Saccharomyces cerevisiae cells as a model, we studied the effects of mitochondrial inhibitors on the competition between wild-type mtDNA and mutant selfish mtDNA in heteroplasmic zygotes. We found that decreasi...
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Mitochondrial dysfunction is a hallmark of aging, and underlies the development of many diseases. Cells maintain mitochondrial homeostasis through a number of pathways that remodel the mitochondrial proteome or alter mitochondrial content during times of stress or metabolic adaptation. Here, using yeast as a model system, we identify a new mitochondrial degradation system that remodels the mito...
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Roughly 10 years ago, a small number of yeast labs isolated a collection of mutants that missort the enzyme carboxypeptidase Y (CPY) in an attempt to unravel vacuolar protein sorting, a process that is closely related to lysosomal enzyme sorting in mammals. They came up with an overwhelming number of VfS genes-more than 50 so far-and the screen is not saturated (see Stack et al., 1995b). How ca...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 1993
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.4.1.21